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Prostate Cancer and Diet
Animal Fat (Bad) and Soy (Good) May Cause 10-Fold Difference in U.S. vs. Japan
10/21/2004 12:39:00 PM

LOS ANGELES, Oct 21, 2004 /PRNewswire via COMTEX/ -- A just-published research study by Urological Sciences Research Foundation may help explain a quandary that has perplexed medical scientists for decades: why is prostate cancer so much more common in the West than in Asia? Diet has long been chief suspect for the difference. The new study compared dietary influences on prostate tissues of Japanese men who spent their life in Japan vs. other Japanese men who spent their life in the U.S. The Western diet, relatively rich in animal fat and poor in soy, was found to exert cancer-causing influences that could be traced directly into prostate tissues.

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"This study is important because it's among the first to look directly at tissues, in an attempt to link diet and cancer," commented Professor Alan Partin of Johns Hopkins University. The side-by-side tissue comparison appears in the October issue of the medical journal Urology and is the product of a 5-year collaboration between U.S. and Japanese scientists.

Diet has long been thought to influence development of prostate (and other) cancers that are common in Western countries and rare in Asia. As much as a 10-fold greater occurrence of prostate cancer in the U.S., compared to Japan and other Asian countries, has been observed. When Asian men migrate to Western countries and adopt a Western lifestyle, the protection begins to disappear within one generation.

Now a linkage between diet and cancer appears to be explained at the tissue level. "Oxidative damage from saturated fat (in Western diet) and a protective effect from soy phytoestrogens (in traditional Japanese diet) are possible mechanisms," the authors write. The authors speculate that if further research confirms these findings, "... dietary modification would become an important public health issue and interest in nutrition-related treatment methods might evolve."

"Cancer can be caused by both hereditary and environmental factors," according to principle author Leonard S. Marks, M.D., of UCLA and Urological Sciences Research Foundation (USRF). Dr. Marks said, "We chose to study prostate cancer in men with the same genetics (all of Japanese descent), but with differing diets -- one Eastern and one Western -- to see if dietary differences translate into differing tissue effects." And this does seem to be the case.

The mechanism of cancerous change appears to be different, determined by dietary influences on how fat is handled by the prostate tissues and how certain enzyme systems known as caspases operate within the tissues. And despite fundamental genetic homogeneity of the two groups, the genetic material (DNA) in the prostate cells was different between the two groups, suggesting the possibility of a gene-nutrient interaction.

The Japanese-American men in the study were all born in Los Angeles or Hawaii and their body composition was measurably different from those native Japanese men who had spent their lives in the Nagoya, Japan area. Tissue and dietary data were gathered by Dr. Marks and colleagues in Los Angeles with the help of L.A. urologists George Yamauchi and Yuichi Ito, and in Nagoya, Japan

by Dr. Munekado Kojima. Tissue studies were performed at Johns Hopkins University and dietary studies at the UCLA Center for Human Nutrition.

The study was completed under the auspices of the UCLA Office for Protection of Human Subjects and was supported by grants from The Prostate Cancer Foundation of Santa Monica, CA and the Pardee Foundation of Midland, MI. George Takei of Star Trek fame served as ombudsman to the Japanese- American community in Los Angeles. The study was conceived and coordinated at Urological Sciences Research Foundation (USRF) (, a non-profit research corporation (501c3) based in Culver City, CA.

Attached photograph: . Touring the Japanese-American National Museum in Los Angeles are George Takei (museum founder and Star Trek's 'Mr. Sulu') and principle study author Leonard S. Marks, M.D.


     Leonard S. Marks, M.D.

     USRF Offices:
     Phone: 310-559-9800 (24 hr)
     Fax: 310-838-8910

SOURCE Urological Sciences Research Foundation

USRF Offices, +1-310-559-9800, or fax, +1-310-838-8910; or
Leonard S. Marks, M.D.,, for Urological Sciences Research

Copyright (C) 2004 PR Newswire. All rights reserved.

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