This page is being served from the Urological Sciences Research Foundation web repository, and was originally posted between 1996-2008. In January 2009 USRF’s founder, Dr. Leonard S. Marks and his staff joined UCLA’s Department of Urology where they are continuing their research. Click for more information.

Urological Sciences Research Foundation - USRF

PDE Inhibition and Smooth Muscle Relaxation - Phosphodiesterase (PDE) is an enzyme that causes breakdown of cyclic GMP, which is the direct intracellular mediator in the nitric oxide pathway.

 

Source: T.Lue, NEJM 342:1802, 2000

this is a navigational image map, please load this image to continue.