Prostate specific antigen (PSA) has for 20 years been widely used as a screening
test for prostate cancer, and it was once called, ‘the most meaningful and useful
tumor marker in all of cancer biology (T.A. Stamey, Monogr.Urol. 10: 45, 1989).’
However, experience over the past 2 decades has somewhat dampened the early
enthusiasm for use of PSA as a screening test. In the following slides, we
outline the 10 great foibles of using PSA as a screening test for prostate cancer.
NOTE: The value of PSA in the follow-up of men who have already been diagnosed
has never been challenged.