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Slide 7 of 14

 
Foible No. 4B. The BPH effect obfuscates cancer specificity of PSA levels in another way (B). On a gram-per-gram basis, the concentration of PSA in BPH tissue is actually several fold higher than in CaP tissue. In the above study, tissue PSA levels were measured in matched cancerous and benign tissues from radical prostatectomy specimens. In almost every pair, the PSA level was much higher in benign tissue than malignant tissue. Because of this difference, PSA would not be expected to be a good cancer marker.

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