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Slide 10 of 14

 
Foible No. 7. Surgical procedures on the prostate to relieve symptomatic BPH can dramatically alter serum PSA levels, because normally, the transition zone is the main source of serum PSA. Best known of such procedures is TURP, trans-urethral resection of the prostate. The endoscopic depictions (above, Left) show the defect that TURP leaves in the prostate. The chart (above, Right) shows the marked decrease in serum PSA levels associated with such a defect. In a large group of men undergoing TURP for BPH, serum PSA levels decreased from 3.0 ng/ml to 0.7 ng/ml as a result of the operation, and the levels stay low indefinitely. New minimally-invasive treatments for BPH may also affect serum PSA levels, though the effect of such procedures (TUMT, TUNA, VLAP, etc) is not as well-documented.

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