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Slide 12 of 14

 
Foible No. 9. The Prostate Cancer Prevention Trial, from which the above chart is taken, showed that when men undergo prostate biopsy regardless of serum PSA levels, some 15% of the cancers found are in men with PSA levels below 4.0 ng/ml, ie ‘normal.’ Even in men with aggressive tumors (Gleason scores > 7), PSA levels may be relatively low. In another publication from PCPT, the authors conclude, “There is no cutpoint of PSA with simultaneous high sensitivity and high specificity for monitoring healthy men for prostate cancer...(JAMA 294:66, 2005).”

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