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Foible No. 9. The Prostate Cancer Prevention Trial, from which the above
chart is taken, showed that when men undergo prostate biopsy regardless of serum
PSA levels, some 15% of the cancers found are in men with PSA levels below 4.0
ng/ml, ie ‘normal.’ Even in men with aggressive tumors (Gleason scores > 7),
PSA levels may be relatively low. In another publication from PCPT, the authors
conclude, “There is no cutpoint of PSA with simultaneous high sensitivity and high
specificity for monitoring healthy men for prostate cancer...(JAMA 294:66, 2005).”
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